Ziac
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• The use of alcohol should be limited.1
• Ziac may contribute to deficiencies in Co-Q-10, magnesium, potassium, zinc, and sodium.2
• Natural licorice products, Ginseng , Ginkgo, and Ephedra (Ma huang) may interfere with antihypertensive medications and should be avoided with high blood pressure.3
• Some herbs possess diuretic properties that may intensify the action of antihypertensive drugs, which could result in an excessive lowering of blood pressure. Such herbs include: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain4
References1 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 143.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Shand, D.G.: Clinical pharmacology of the beta-blocking drugs: implications for the postinfarction patient. Circulation, 1983, 67(Supp 1): 12-15.
2 Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III--inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pathol Pharmacol, 1975, 12(3):533-40.
2 Martin B, Milligan K. Diuretic-associated hypomagnesiumia in the elderly. Arch Intern Med 1987;147:1768-71.
2 Kroenke K, Wood DR, Hanley JF. The value of serum magnesium determination in hypertensive patients receiving diuretics. Arch Intern Med. 1987;147:1553-56.
2 Whang R, Whang DD, Ryan MP. Refractory potassium repletion, a consequence of magnesium deficiency. Arch Intern Med 1992;152:40-45.
3 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
3 Farese, RV et al., Licorice-induced hypermineralcorticoidism. NEJM. 1991, 325:1,1223-1,227.
3 Shaw D et al. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Safety 1997;17:342-56.
3 Shintani S, Murase H, Tsukagoshi H, Shiigai T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of two cases and review of the literature. Eur Neurol 1992;32:44-51.
3 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 Shaw D et al. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Safety 1997;17:342-56.
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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