Isoniazid
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Take medication one hour before or two hours after meals, food decreases absorption.1
• May take with food if stomach upset occurs.2
• Vitamin B-6 (Pyridoxine) supplements (25-50mg) daily may help to prevent peripheral neuropathy.3
• Vitamin D, calcium and folic acid levels are lowered in the body when using Isoniazid .4
• Avoid alcohol5
• Avoid high tyramine or histamine foods.6
• Niacin may be depleted with Isoniazid7
• Vitamin E and magnesium may also be depleted with long term isoniazid use. Discuss supplementation with a multivitamin with a pharmacist.8
• The component glycyrrhizin found in Licorice may be helpful in treating tuberculosis with isoniazid.9
• Echinacea herb and root should not be used in diseases such as tuberculosis or autoimmune diseases.10
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edtion, 1999
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
3 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 147.
3 Mandell GL, Petri WA Jr . Antimicrobial Agents: Drugs used in the chemotherapy of tuberculosis, Mycobacterium avium complex disease and leprosy. In Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed. New York: McGraw-Hill, 1996, 1158.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 231-32 [review].
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Pronsky, Z Food Medication Interactions, 11th edition, 1999
7 Matsui MS, and Rozovski SJ. Drug Nutrient Interaction. Clin Ther. 1982 4(6):423-40
7 Holt GA. Food & Drug Interactions. Chicago, Precept Press, 1998, 146–47.
7 Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 231-32 [review].
8 Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 231-32 [review].
8 Holt GA. Food & Drug Interactions. Chicago, Precept Press, 1998, 146-47.
9 Aoki K, Tokiwa T, Yamamoto T, Teramatsu T. Combined treatment of pulmonary tuberculosis with glycyrrhizin and INH. Acta Tubercul Japon 1963;13:32-39
10 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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