Plendil
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• The use of alcohol should be limited.1
• Grapefruit and grapefruit juice may enhance Plendil, possibly causing an excessive lowering of blood pressure. This medication should be taken with water and not consumed within two hours of grapefruit products.2
• Avoid natural Licorice products, Ginseng, and Ephedra (Ma huang), which may contribute to hypertension.3
• The following herbs may lead to an excessive lowering of blood pressure or increased side effects: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot4
References1 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 143.
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Bailey, DG et al, Interaction of citrus juices with fleodipine and nifedipine, Lancet. 1991; 337:268.
2 Bailey, DG et al. Formulation dependent interaction between felodipine and grapefruit juice. Clin.Pharmacolo. Ther. 1990;47:181 Abstract.
2 Edgar, B et al: Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of Felodipine - and its potential clinical relevance. Eur. J. Clin. Pharm. 1992, 42:313-317.
2 Lundahl J et al. Relationship between time of intake of grapefruite juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects. Eur J Clin Pharmacol. 1995;49:61.
2 Bailey DG, Dresser GK, Kreeft JH, et al. Grapefruit juice-felodipine interaction: Effecct of segments and an extract from unprocessed fruit. Clin Pharmacol Ther 2000; 67(2): 107.
2 Fuhr U. "Drug Interactions with Grapefruit Juice." Drug Safety 1998; (4): 251-272.
3 Farese, RV et al., Licorice-induced hypermineralcorticoidism. NEJM. 1991, 325:1,1223-1,227.
3 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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