Indomethacin
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Indomethacin inhibits prostaglandins, which reduces renin and aldosterone, and, in turn, reduces potassium excretion and causes hyperkalemia. nutritional concerns: Individuals taking indomethacin should be cautious in using KCl (such as "No SaltŪ"). Serum potassium levels need to be monitored.1
• nutrient affected by drug: Iron Indomethacin causes anemia by two possible mechanisms. It can cause peptic ulceration or gastrointestinal bleeding and consequently may lead to anemia. Further, research indicates that prostaglandins are necessary for the normal iron metabolism and for erythropoiesis. Indomethacin's primary action is prostaglandin inhibition. Note: Indomethacin has also been associated with aplastic anemia. Any instance of anemia in an individual using indomethacin should be thoroughly evaluated due to differing possible causes. Supplementation with iron in individuals using indomethacin may be indicated but should only be initiated after consultation with the prescribing physician and/or a nutritionally trained healthcare provider.2
• nutrient affecting drug toxicity: Antioxidants. mechanism: Indomethacin causes gastric ulceration via free radicals. Supplementation with anti-oxidants in individuals using indomethacin may be indicated but should only be initiated after consultation with the prescribing physician and/or a nutritionally trained healthcare provider.3
References1 Akbarpour F, Afrasiabi A, Vaziri ND. Severe hyperkalemia caused by indomethacin and potassium supplementation. South Med J 1985 Jun;78(6):756-757
2 Ganchev T, Negrev N, Mileva V. Effects of indomethacin on erythropoiesis and plasma iron in rats. Acta Physiol Pharmacol Bulg 1989;15(2):53-57.
3 Akbarpour F, Afrasiabi A, Vaziri ND. Severe hyperkalemia caused by indomethacin and potassium supplementation. South Med J 1985 Jun;78(6):756-757.
3 Ganchev T, Negrev N, Mileva V. Effects of indomethacin on erythropoiesis and plasma iron in rats. Acta Physiol Pharmacol Bulg 1989;15(2):53-57.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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