Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Foods high in fat, can delay peak concentration of the drug, but overall absorption is increased.1
• The drug can cause gastrointestinal pain and diarrhea. If this persists talk to a doctor or pharmacist.2
• Drink plenty of fluids while on this medication and do not use the drug if dehydration is present.3
• Avoid herbs with antiplatelet or anticoagulant properties like: angelica,anise, asafoetida, capsicum, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng (Panax), horse chestnut, horseradish, licorice, meadowsweet, prickly ash, onion, passionflower, poplar, red clover, turmeric, wild carrot, wild lettuce, and willow with celebrex. Avoid their use together.4
• Patients in the clinical trial taking 400 mg. of Celebrex twice daily had a 3.4 times greater risk of CV events compared to placebo. For patients in the trial taking 200 mg. of Celebrex twice daily, the risk was 2.5 times greater. The average duration of treatment in the trial was 33 months. A similar ongoing study comparing Celebrex 400 mg. once a day versus placebo, in patients followed for a similar period of time, has not shown increased risk. Physicians should consider this evolving information in evaluating the risks and benefits of Celebrex in individual patients. FDA advises evaluating alternative therapy. At this time, if physicians determine that continued use is appropriate for individual patients, FDA advises the use of the lowest effective dose of Celebrex. Patients who are currently taking Celebrex and have questions or concerns about the drug should discuss them with their physicians.Celebrex was approved in 1998 for the treatment of osteoarthritis and rheumatoid arthritis. Previous large studies of Celebrex, including clinical trials and epidemiology studies, have not suggested the sort of CV risk found in the NCI polyp study. Because similar long-term studies of other products in the class of non-steroidal anti-inflammatory drugs (NSAIDS), other than Cox-2 inhibitors have not been done, it is not known whether other NSAIDS pose a similar risk.5
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
4 Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. : Eclectic Medical Publications, 1998.
4 PDR for Herbal Medicines. 2nd edition: Medical Economics Company, Inc.,2000.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.