Zagam
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Drink plenty of fluids unless otherwise directed.1
• Calcium, magnesium, aluminum, zinc may reduce absorption and hence the effectiveness of fluoroquinolone antibiotics. Avoid consuming dairy products and/or supplements containing calcium at least two hours after ingesting this medication.2
• Antibiotics kill bacteria, including beneficial flora in the gut, which may affect digestion and/or elimination. Supplementation with acidophilus and/or bifidus may help to replace beneficial flora.3
• Avoid caffeine with zagam, the drug may decrease caffeine clearance and thereby increase side effects.4
• Avoid cola, guarana and mate with zagam due to their caffeine content.5
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Lim D and McKay M. Food-drug interactions. Drug Information Bulletin (UCLA Dept. of Pharmaceutical Services) 15(2): 1995.
3 Bengmark S & Gianotti L: Nutritional support to prevent and treat multiple organ failure. World J Surg, 1996 May, 20:4, 474-81.
3 Cummings JH, Macfarlane G: Role of intestinal bacteria in nutrient metabolism, JPEN J Parenter Enteral Nutr, 1997, 21(6): 357-65.
3 Gorbach SL: Bengt E. Gustafsson Memorial Lecture, Function of the Normal Human Microflora, Scand J Infect Dis Suppl, 1986, 49:17-30
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Carbo M, et al. Effect of quinolones on caffeine disposition, Clin Pharmacol Ther 1989;45:234-40.
5 Barnett G, Segura J, de la Torre R, Carbo M. Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition. Eur J Clin Pharmacol. 1990;39(1):63-9.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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