Chlorpropamide
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Avoid alcohol with this drug, severe reaction is possible1
• Increased appetite and weight is possible with the use of this drug.2
• Co-Q-10 may effect glucose levels if used together with this drug.3
• Avoid magnesium supplements and vitamin E or antacids containing magnesium with chlorpropamide, it can increase hypoglycemic effects of the drug.4
• Potatoes can interfere with blood sugar levels and chlorpropamide dosage may require adjustment.5
• Avoid L-carnitine and chromium with this medication, they may have additive blood sugar lowering effects.6
• Bitter melon, burdock, dandelion, fenugreek, ginseng, onion, garlic, juniper, myrrh, nettle, sage and tansy and bilberry all have hypoglycemic effects and chlorpropamide dosage may need to be adjusted if used together with these agents.7
• Due to the known interaction between this medication and salicylates, it would be advisable to avoid herbs with salicylate properties like: meadowsweet, poplar and white willow.8
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Human Hypertens 13: 203-208, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
5 Gannon MC, et al. Diabetes Care 1993;16:874.
5 The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
6 Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr. 1997 Oct;16(5):404-10.
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
7 Bever BO and Zahnd GR. Plants with oral hypoglycemic action. Q J Crude Drug Res 17: 139-196, 1979.
7 Mathew PT and Augusti KT. Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes mellitus-a preliminary report. Indian J Physiol Pharmacol 19: 213-217, 1975
7 Cignarella A, Nastasi M, Cavalli E, et al. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res. 1996;84:311-322.
7 Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 17: 277-282, 1986.
7 Yaniv Z, Dafni A, Friedman J, et al. Plants used for the treatment of diabetes in Israel. J Ethnopharmacol 19(2): 145-151, 1987.
8 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
8 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
8 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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