Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid alcohol, which may intensify the action of Endocet.1
• Use of over three grams of vitamin C has been associated with decreased acetaminophen clearance time.2
• Foods that are high in carbohydrates, pectin and vegetables like broccoli, brussel sprouts and cabbage can interfere with acetaminophen absorption.3
• Herbs with sedative properties may intensify the effects of Endocet, and should not be used concurrently. These herbs include: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa.4
• Milk thistle extract has a protectant effect on the liver with long term acetaminophen use.5
• Tobacco decreases acetaminophen blood levels.6
References1 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 263.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Houston JB, Levy G. Drug biotransformation interactions in man. VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:121-21.
3 Holt GA. Food and Drug Interactions. Chicago: Precept Press, 1998
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Campos, R. et al. Silybin Dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Medica. 1989: 55:417.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.