Propranolol Hydrochloride
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Possible deficiencies include: Co-Q-10, and Chromium1
• Avoid alcohol.2
• Do not take propranolol with calcium or antacids. This may decrease absorption of the drug.3
• Avoid high doses of vitamin C (more than 2 grams/day) because it can decrease metabolism and absorption of the drug.4
• Use this medication with caution in diabetes because it can prolong hypoglycemia.5
• Tobacco can reduce the effects of propranolol.6
• Avoid natural licorice.7
• These herbs may increase the side effects or adverse reactions of Propranolol due to their cardiac properties: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot8
• Black cohosh, poplar, sweet birch, and wintergreen and willow bark all have salicylate properties which may interfere with beta blockers.9
• Some herbs possess diuretic properties that may intensify the action of antihypertensive drugs. This could result in an excessive lowering of blood pressure. Such herbs include: Black Radish, Blue Cohosh, Cleavers, Couchgrass, Elder, Hops, Horsetail, Juniper, Black Safflower, and Sassafras10
• Ephedra should not be taken together with other CNS stimulants or circulatory agents (digitoxin, beta-blockers, etc.). Theoretically, a single high dose could result in irregular heartbeats.11
• Cola, Guarana, Mate are some caffeine containing herbs that should be avoided with beta blockers.12
• Melatonin can reverse the sleep effects of propranolol and atenolol.13
References1 Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III - inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pathol Pharmacol, 1975, 12(3):533-40
1 Mountokalakis T, Dourakis S, Karatzas N, et al: Zinc deficiency in mild hypertensive patients treated with diuretics, J Hypertens Suppl, 1984, 2(3):S571-2
1 Roeback JR Jr, Hla KM, Chambless LE, Fletcher RH. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers. A randomized, controlled trial. Ann Intern Med, 1991;115(12):917-924
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Facts and Comparisons, Clinsphere 2.0, Wolters Kluwer Company, 2000
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Pronsky, Z Food Medication Interactions, 11th edition, 1999
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Pronsky, Z Food Medication Interactions, 11th edition, 1999
8 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
8 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
8 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
10 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
10 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
11 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
12 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
13 Stoschitzky K, Sakotnik A, Lercher P, et al. Influence of beta-blockers on melatonin release. Eur J Clin Pharmacol 1999;55(2):111-115
13 Van Den Heuvel CJ, Reid KJ, Dawson D. "Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin." Physiol Behav, Jun. 1997; 61(6):795-802.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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