Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Daraprim is a folic acid antagonist and long term and higher dosage use( for toxoplasmosis)of this medication can cause folic acid deficiency. Monitor for signs of deficiency and treat accordingly.1
• Take this medication with food to avoid vomiting or anorexia.2
• Daraprim use may also lower vitamin B12 levels. Monitor for signs of deficiency.3
• Para-aminobenzoic acid (PABA) can interfere with Daraprim therapy. Monitor for signs of inadequate drug effects and inform a physician.4
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. AFP 1986;33(2):165-74.
1 Holt, G Food and Drug Interactions: Revised and Expanded Edition, Precept Press, 1998
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
3 Wickramasinghe SN, Litwinczuk RA. Effects of low concentrations of pyrimethamine on human bone marrow cells in vitro: possible implications for malaria prophylaxis. J Trop Med Hyg. 1981 Dec;84(6):233-8.
4 Holt, G Food and Drug Interactions: Revised and Expanded Edition, Precept Press, 1998
4 Watkins WM, Sixsmith DG, Chulay JD, Spencer HC. Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid. Mol Biochem Parasitol. 1985 Jan;14(1):55-61.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.