Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid caffeine with this medication due to possible increases in blood pressure.1
• Avoid foods high in tyramine content (aged meats and cheeses, soy sauce, sauerkraut, beer, etc.) if the medication dose is greater than 10mg due to possible hypertensive reactions.2
• Take with food3
• Avoid ephedrine or Ma Huang with this medication due to possible hypertensive reactions.4
• Avoid St. John's Wort with this medication due to possible increased risk of hypertensive side effects. It is still unclear whether St. John's wort inhibits MAO, however until more is known, it is best to avoid combining these two products.5
• Avoid kava, and valerian with this medication due to possible risk of adverse reactions.6
References1 Holt, G Food and Drug Interactions: Revised and Expanded Edition, Precept Press, 1998
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Livingston MG, Livingston HM. Monoamine oxidase inhibitors. An update on drug interactions. Drug Saf. 1996 Apr;14(4):219-27. Review.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
4 Lefebvre H, Noblet C, Moore N, Wolf LM. Pseudo-phaeochromocytoma after multiple drug interactions involving the selective monoamine oxidase inhibitor selegiline. Clin Endocrinol (Oxf). 1995 Jan;42(1):95-8; discussion 98-9.
5 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
6 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
6 Schelosky L, Raffauf C, Jendroska K, et al. Kava and dopamine antagonism. J Neurol Neurosurg Psychiatry 1995;58(5):639-640.
6 Cupp MJ. Herbal remedies: adverse effects and drug interactions. Am Fam Physician. 1999 Mar 1;59(5):1239-45. Review.
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Baum SS, Hill R, Rommelspacher H. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.