Tolinase
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Avoid alcohol with this medication.1
• Avoid magnesium and vitamin E supplements or antacids containing magnesium with this drug, it can increase hypoglycemic effects of the drug.2
• Coenzyme Q10 may be depleted with long term use of this medication.3
• Avoid high doses of niacin with this medication, it can cause blood sugar levels ot rise dramatically.4
• Avoid L-carnitine and chromium with this medication, they may have additive blood sugar lowering effects.5
• Potatoes can cause blood sugar fluctuations, avoid consuming large quantities of this vegetable with this medication.6
• The following herbs may lower blood sugar levels: Alfalfa, Aloe vera, Bilberry, Burdock, Bitter Melon, Celery, Cornsilk, Damiana, Eucalyptus, Fenugreek, Garlic, Ginger, Panax Ginseng, Goat's Rue, Juniper, Marshmallow, Myrrh, Nettle, Onions, Sage and Tansy.7
• Due to the known interactions between salicylates and this medication, it is best to avoid herbs with salicylate properties like: meadowsweet, poplar, and white willow8
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Holt, G Food and Drug Interactions: Revised and Expanded Edition, Precept Press, 1998
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
2 McBain AM, Brown IR, Menzies DG, Campbell IW. Effects of improved glycaemic control on calcium and magnesium homeostasis in type II diabetes. J Clin Pathol 1988;41:933-35.
3 Kishi T, Kishi H, Watanabe T, et al: Bioenergetics in clinical medicine - studies on coenzyme Q and diabetes mellitus, J Med, 1976, 7(3-4):307-21.
3 Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Human Hypertens 13: 203-208, 1999
4 Schwartz ML. Severe reversible hyperglycemia as a consequence of niacin therapy. Arch Intern Med. 1993 Sep 13;153(17):2050-2.
5 Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
5 Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr. 1997 Oct;16(5):404-10.
6 Gannon MC, et al. Diabetes Care 1993;16:874.
6 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
7 Bever BO and Zahnd GR. Plants with oral hypoglycemic action. Q J Crude Drug Res 17: 139-196, 1979.
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 17: 277-282, 1986.
8 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
8 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
8 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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