Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• The use of alcohol should be avoided or limited. It could increase CNS side effects.1
• Toprol may also contribute to deficiencies in CoQ10.2
• Calcium may interfere with the absorption of Toprol. Consider taking calcium supplements separately from all medications.3
• Take with food to increase drug bioavailability.4
• These herbs may adversely affect the action of Toprol due to their cardiac properties: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot.5
• Natural licorice products, Ginseng and Ephedra (Ma huang) may cause hypertension and should be avoided by those with high blood pressure.6
• Some herbs possess diuretic properties that may intensify the action of antihypertensive drugs, which could result in an excessive lowering of blood pressure. Such herbs include:Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain7
References1 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 143.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Shand, D.G.: Clinical pharmacology of the beta-blocking drugs: implications for the postinfarction patient. Circulation, 1983, 67(Supp 1): 12-15.
2 Product Information: Inderal, propranolol hydrochloride. Wyeth-Ayerst Laboratories, PA. 1993.
2 Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III . Inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pathol Pharmacol, 1975, 12(3):533-40.
3 The Medical Letter Handbook of Adverse Drug Interactions, 1995.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Wang BO, Semple HA. Inhibition of metoprolol metabolism by amino acids in perfused rat livers. Insights into the food effect? Drug Metab Dispos. 1997 Mar;25(3):287-95.
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
6 Farese, RV et al., Licorice-induced hypermineralcorticoidism. NEJM. 1991, 325:1,1223-1,227.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
7 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.