Detrol
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Food increases availability by 53% but the drug may be taken with or without food.1
• Detrol may interact with grapefruit juice due to metabolism by the cytochrome P450 pathway. Avoid using these together.2
• Garlic and melatonin may be inhibitors of CYP3A4 and may therefore interact with detrol.3
• St. John's Wort may be an inducer of CYP3A4 and should be not be used together with detrol.4
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Piscitelli S. Preventing dangerous drug interactions. Platform presentation of the American Pharmaceutical Association Annual Meeting; March 10-14, 2000; Washington, DC.
3 Michalets EL. Update: clinically significant cytochrome p-450 drug interactions. Pharmacotherapy. 1998;18:84-112.
4 Piscitelli S. Preventing dangerous drug interactions. Platform presentation of the American Pharmaceutical Association Annual Meeting; March 10-14, 2000; Washington, DC.
4 Michalets EL. Update: clinically significant cytochrome p-450 drug interactions. Pharmacotherapy. 1998;18:84-112.
4 Roby CA, Anderson GD, Kantor E, Dryer DA, Berstein AH. St John's Wort: effect on CYP3A4 activity. Clin Pharmacol Ther. 2000 May;67(5):451-7.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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