Naproxen
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Avoid alcohol. Alcohol use with this medication heightens the risk of gastric ulceration and bleeding.1
• Naproxen may also hinder absorption of folic acid and vitamin C.2
• Naproxen may raise blood potassium levels, especially in the elderly or in those with poor kidney function.3
• Take Naproxen with food to avoid stomach irritation.4
• Licorice may protect the stomach against NSAID damage.5
• The Food and Drug Administration (FDA) is working with the National Institutes of Health to review the available scientific information on naproxen following the decision of the National Institute on Aging to halt a clinical trial studying non-steroidal anti-inflammatory drugs in patients at risk of developing Alzheimer's disease. Preliminary information from the study showed some evidence of increased risk of cardiovascular events, when compared to placebo, to patients taking naproxen. In the meantime, FDA advises patients who are currently taking over-the-counter naproxen products to carefully follow the instructions on the label. Patients should not exceed the recommended doses for naproxen (220 milligrams twice daily) and should not take naproxen for longer than ten days unless a physician directs otherwise. Patients with questions about naproxen should consult their physicians.6
References1 Graedon J, Graedon, T: The People’s Guide to Deadly Drug Interactions, 1995, p. 149.
1 Holt GA. Food & Drug Interactions. Chicago, Precept Press, 1998, 137-38.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Roe DA: Drug-Induced Nutritional Deficiencies. 2nd ed. Westport, Conn: AVI Publ Co; 1985.
2 Hodges R. Nutrition in Medical Practice. Philadelphia: W. B. Saunders, 1980, 323-31 [review].
2 Baggott JE, Morgan SL, Ha T, et al: Inhibition of folate-dependent enzymes by nonsteroidal anti-inflammatory drugs, Biochem J, 1992, 282(pt 1):197-202.
2 Molloy TP and Wilson CW. Protein-binding of ascorbic acid. 2. Interaction with acetylsalicylic acid. Int J Vitam Nutr Res 50: 387-392, 1980.
2 Das N and Nebioglu S. Vitamin C: aspirin interactions in laboratory animals. J Clin Pharm Ther 17: 343-346, 1992.
2 Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1634.
3 Bailie GR. Acute renal failure. In Applied Therapeutics: The Clinical Use of Drugs, 6th ed. Vancouver, WA: Applied Therapeutics, 1995, 29-33.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Hydacki JJ. The Concise Essential Guide to Prescription Drugs. HarperCollins, 1997.
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 1979;14:605-7.
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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