Norvir
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Take with food.1
• Grapefruit juice may enhance the pharmocologic effects of this drug.2
• The following herbs: Adonis, Digitalis lanata, English hawthorn, Lily-of-the-Valley, Scotch broom herb, and Squill have antiarrhythmic properties. Based on known interactions between norvir and antiarrythmics, these herbs should be avoided to decrease risk of adverse effects.3
• Avoid St. John's Wort while taking protease inhibitors in view of the known interaction between St. John's Wort and Indinavir. St. John's Wort may decrease the blood levels of drug.4
• The following herbs: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa have sedative or hynotic effects. In view of known interactions between certain sedative hynotics and norvir, consult your physician or pharmacist before using these herbs with norvir.5
• Astragalus may interact and enhance side effects of antiviral agents such as norvir.6
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-I protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol. 1999;48:543-552
2 Kupferschmidt HHT, Fattinger DE, Ha HR et al. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor in man. Br J Clin Pharmacol 1998: 45: 355-9.
3 PDR (Physician's Desk Reference) for Herbal Medicines. Second edition. Medical Economics Company. Montvale, NJ. 2000: 205, 259.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Piscitelli SC, Burstein AH, Chaitt D, et al. Indinavir concentrations and St. John's wort. Lancet 355: 547-548, 2000.
4 Risk of drug interactions with St. John's wort and indinavir and other drugs. URL: www.fda.gov/cder/drug/advisory/stjwort.htm
5 PDR (Physician's Desk Reference) for Herbal Medicines. Second edition. Medical Economics Company. Montvale, NJ. 2000
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Upton R (ed). Astragalus Root: analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia; 1999;1-25
6 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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