Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Preliminary reports suggest levels of antioxidants like vitamin C and E are reduced with the use of chemotherapeutic agents. Whether supplementation with antioxidants is helpful in humans needs to be further investigated.1
• Long term treatment with Cytoxan may increase the risk of serious infections due to immunosuppression. Monitor for signs of infection.2
• This medication should be taken on an empty stomach. Howver, if stomach upset occurs it may be taken with food.3
• Drink adequate fluids with this medication to prevent kidney damage.4
• Avoid astragalus use with Cytoxan due to its immunostimulant properties. It may interfere with drug therapy.5
• Due to the known interaction between Cytoxan and Coumadin, avoid these herbs with blood thinning properties due to possible anticoagulant effects: Angelica, anise, arnica, asafoetida, bogbean, boldo, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng (Panax), horse chestnut, licorice, meadowsweet, prickly ash, passionflower, poplar, quassia, red clover, turmeric, and willow.6
References1 Jaakkola K, Lahteenmaki P, Laakso J, et al. Treatment with antioxidant and other nutrients in combination with chemotherapy and irradiation in patients with small-cell lung cancer. Anticancer Res 1992;12:599-606.
1 Taper HS, de Gerlache J, Lans M, Roberfroid M. Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pre-treatment. Int J Cancer 1987;40:575-79.
1 Ghaskadbi S, Rajmachikar S, Agate C, Kapadi AH, Vaidya VG. Modulation of cyclophosphamide mutagenicity by vitamin C in the in vivo rodent micronucleus assay. Teratog Carcinog Mutagen. 1992;12(1):11-7.
1 Jonas CR, Puckett AB, Jones DP, Griffith DP, Szeszycki EE, Bergman GF, Furr CE, Tyre C, Carlson JL, Galloway JR, Blumberg JB, Ziegler TR. Plasma antioxidant status after high-dose chemotherapy: a randomized trial of parenteral nutrition in bone marrow transplantation patients. Am J Clin Nutr. 2000 Jul;72(1):181-9.
1 Ghosh S, Ghosh D, Chattopadhyay S, Debnath J. Effect of ascorbic acid supplementation on liver and kidney toxicity in cyclophosphamide-treated female albino rats. J Toxicol Sci. 1999 Aug;24(3):141-4.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.