Doxepin
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• There is an increased requirement for riboflavin and maybe Co Q10.1
• These nutrients may be considered for supplementation: vitamin B complex [ folate, vitamin B-6, vitamin B-12], and vitamin E.2
• Take with food to avoid stomach upset. The oral concentrate of the medication is incompatible with grape juice or carbonated drinks.3
• Limit or avoid caffeine.4
• Avoid alcohol5
• Avoid belladonna, henbane, mandrake, scopolia, and bittersweet nightshade with doxepin because it can increase anticholinergic side effects of the drug.6
• Avoid SAMe with doxepin, it could increase side effects or cause serotonin syndrome.7
• Tobacco increases the elimination of tricyclic antidepressants like doxepin.8
• Avoid St. John's Wort with doxepin because it can increase adverse effects.9
• Yohimbe can increase or decrease blood pressure if used together with tricyclic antidepressants. Avoid using these agents together.10
References1 Kishi T, et al: Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by Coenzyme Q10, Biomedical and Clinical Aspects of Coenzyme Q10, 1980, 2:139-54
1 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
1 Pinto, J.T. & Rivlin, R.S. : Drugs that promote renal excretion of riboflavin. Drug Nutrient Interactions, 1987, 5: 143-151.
2 Bell IR, Edman JS, Morrow FD, et al: Brief communication - Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive function, J Am Coll Nutr, 1992, 11(2):159-63
2 Edelbroek PM, Zitman FG, Schreuder JN, et al: Amitriptyline metabolism in relation to antidepressive effect, Clin Pharmacol Ther, 1984, 35(4):467-73
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Blumenthal M, et al. ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Berlanga C, et al. "Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine." Psychiatry Res, 1992; 44(3):257-62.
7 Friedel HA, Goa KL, Benfield P. "S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism." Drugs, 1989; 38(3):389-416.
8 Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
9 Miller LG. "Herbal Medicinals. Selected Clinical Considerations Focusing on Known or Potential Drug-Herb Interactions." Arch Intern Med, 1998;158:2200-211
9 The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 2000
9 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996
9 Pronsky, Z Food Medication Interactions, 11th edition, 1999
10 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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