Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Potassium and magnesium may be depleted with long term use of the drug. Monitor levels , supplements may be necessary.1
• Chlorothiazide, a thiazide diuretic, can increase calcium levels in the body. Monitor levels and do not use calcium or vitamin D supplements without physician consultation.2
• Chlorothiazide may increase glucose levels, use with caution in diabetics.3
• Avoid or limit alcohol4
• Thiazide diuretics also may cause zinc deficiency. Supplementation may be needed.5
• Avoid licorice with chlorothiazide because it could deplete potassium and cause electrolyte imbalances.6
• Aloe, cascara sagrada, senna ,rhubarb and buckthorn berry all increase potassium loss caused by thiazide diuretics.7
• Avoid these herbs with chlorothiazide due to possible increased side effects: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot8
References1 al-Ghamdi SM, Cameron EC, and Sutton RA. Magnesium deficiency: pathophysiologic and clinical overview. Am J Kidney Dis 24: 737-752, 1994.
1 Dorup I. Magnesium and potassium deficiency. Its diagnosis, occurrence and treatment in diuretic therapy and its consequences for growth, protein synthesis and growth factors. Acta Physiol Scand Suppl 618: 1-55, 1994
1 Martin BJ and Millian K. Diuretic-associated hypomagnesemia in the elderly. Arch Intern Med 1987, 147: 1768-1771, 1987.
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
1 Whang R, Whang DD, and Ryan MP. Refractory potassium repletion a consequence of magnesium deficiency. Arch Intern Med 152: 40-45, 1992.
2 Goodman L and Gilman A. The pharmacological basis of therapeutics, 9th ed. Hardman J, et al. (eds.). New York: McGraw-Hill, 1996: 702.
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Riis B and Christiansen C. Actions of thiazide on vitamin D metabolism: A controlled therapeutic trial in normal women early in the postmenopause. Metabolism 34: 421-424, 1985.
2 Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1636.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Cohanim M and Yendt ER, The Effects of Thiazides on Serum and Urinary Zinc in Patients With Renal Calculi, Johns Hopkins Med J, 1975, 136(3):137-41
5 Mountokalakis T, Dourakis S, Karatzas N, et al, Zinc Deficiency in Mild Hypertensive Patients Treated with Diuretics, J Hypertens Suppl, 1984, 2(3):S571-2
5 Reyes AJ, Leary WP, Lockett CJ, et al. Diuretics and zinc. S Afr Med J 62: 373-375, 1982
6 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Shintani S, Murase H, Tsukagoshi H, and Shiigai T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of two cases and review of the literature. Eur Neurol 32: 44-51, 1992.
7 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
8 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
8 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
8 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.