Imipramine
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• May take medication with food to decrease stomach upset.1
• Limit or avoid caffeine in diet.2
• Vitamin B1, B2 , B6 and Co-Q-10 may need to be supplemented with long term use of the medication.3
• Avoid alcohol4
• There may be an increase in appetite, particularly for sweets.5
• Tricyclic antidepressants may display additive anticholinergic effects with Thorn apple, (Jimsen weed).6
• Tobacco speeds the elimination of tricyclic antidepressants.7
• Tricyclic antidepressants and SAMe may interact to increase serotonergic side effects.8
• Hypertension may occur with yohimbe and tricyclic antidepressants e.g. Imipramine9
• Tricyclic antidepressants may decrease the effectiveness of Indian Snakeroot.10
• The German Commission E has noted an interaction or possibility of an interaction between tricyclic antidepressants and these herbs: Belladonna leaf and root , Henbane leaf, Kava Kava, Scopolia root11
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Bezchlidnyk, K.Z. : Should psychiatric patients drink coffee? Can. Med. Ass. J. 1981, Feb 15, 124:4.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Kishi T, et al: Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by Coenzyme Q10, Biomedical and Clinical Aspects of Coenzyme Q10, 1980, 2:139-54
3 Bell IR, Edman JS, Morrow FD, et al: Brief communication - Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive function, J Am Coll Nutr, 1992, 11(2):159-63
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Hudson CJ: Tricyclic antidepressants and alcoholic blackouts. J Nerv Ment Dis 1981; 169:381.
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Paykel ES, Mueller PS & De la Vergne PM: Amitriptyline, weight gain and carbohydrate craving: a side effect. Br J Psychiatry 1973; 123:501.
6 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
8 Berlanga C, et al. "Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine." Psychiatry Res, 1992; 44(3):257-62.
8 Iruela LM, et al. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psych 1993; 150:522.
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
10 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
11 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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