Vioxx
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Avoid large doses of vitamin E and NSAID's together, there may be a possible risk of increased bleeding.1
• Deglycyrrhizinated licorice may be a stomach protectant when NSAID's are used long term.2
• Avoid using ginkgo with NSAID's due to their potential to increase bleeding.3
• Avoid these herbs with NSAID's like Vioxx due to their potential to increase bleeding times: dong quai, feverfew, garlic, ginger, horse chestnut, and red clover.4
• Merck & Co. withdrew Vioxx worldwide after post market studies confirm that Vioxx raises the risk of serious cardiovascular events including heart attack and stroke. About 2 million people worldwide were on the drug at the time of its withdrawal. In addition to heart attacks and strokes, Vioxx has been associated with several other life-threatening side effects, including blood clots, angina and nonbacterial meningitis, severe intestinal damage, ulcerations and bleeding, and kidney damage.5
References1 Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.
2 Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 14: 605-607, 1979.
2 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
3 Rosenblatt M and Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 336(15): 1108, 1997.
3 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
3 Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996; 46: 1775-76
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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