Trileptal
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Avoid Alcohol1
• Take with food or milk to avoid stomach upset.2
• Grapefruit juice may interact with the drug, avoid taking together.3
• Long term use of anticonvulsants may decrease biotin levels in the body.4
• Ephedra or Ma huang may interact with anticonvulsants, because of its seizure potential.5
• 'Psyllium can interact with this medication and should not be used together.6
• Ephedra or Ma huang may interact with anticonvulsants, because of its seizure potential.7
• 'Psyllium can interact with this medication and should not be used together.8
• Sedating herbs, such as valerian, hops, passionflower, St. John’s wort, and chamomile,may potentially interact with your treatment and should be discussed with your physician.9
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
3 Garg SK, et al. "Effect of grapefruit juice on carbamazepine bioavaiolability in patients with epilepsy." Clin Pharmacol Ther, 1998; 64: 286-88.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
4 Mock DM, Dyken ME. Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants. Neurology 1997;49:1444-47.
4 Mock DM, Mock NI, Nelson RP, Lombard KA. Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy. J Pediatr Gastroenterol Nutr 1998;26:245-50.
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 Cupp MJ. Herbal remedies: adverse effects and drug interactions. Am Fam Physician. 1999 Mar 1;59(5):1239-45. Review.
6 Etman M. Effect of a bulk forming laxative on the bioavailablility of caramazepine in man. Drug Devel Indus Pharm, 1995; 21:1901-906
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Cupp MJ. Herbal remedies: adverse effects and drug interactions. Am Fam Physician. 1999 Mar 1;59(5):1239-45. Review.
8 Etman M. Effect of a bulk forming laxative on the bioavailablility of caramazepine in man. Drug Devel Indus Pharm, 1995; 21:1901-906
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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