Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• This diuretic causes loss of potassium, magnesium, and sodium. Supplementation of these nutrients with long term use of the medication may be necessary.1
• Avoid using calcium and vitamin D supplements without consulting a physician. There is an increased risk of hypercalcemia associated with this drug.2
• Co-Q-10 may be depleted with this drug with long term use. Discuss the possible benefits of supplementation with a physician or pharmacist.3
• Ginkgo may increase blood pressure if used with thiazide diuretics.4
• Avoid natural licorice, buckthorn, aloe(dried leaf), cascara sagrada, rhubarb plant and senna with thiazide diuretics. There is an increased risk of potassium loss.5
• These herbs possess diuretic action and should be avoided with zaroxolyn: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain6
References1 Dychner T, Wester PO: Potassium/Magnesium depletion in patients with cardiovascular disease, Am J Med, 1987, 82(3A):11-7
1 Gettes LS: Electrolyte abnormalities underlying lethal and ventricular arrhythmias, Circulation, 1992, 85(1 suppl):170-6
1 Hollifield JW: Potassium and magnesium abnormalities - diuretics and arrhythmias in hypertension, Am J Med, 1984, 77(5A):28-32
1 Nicholls MG: Interaction of diuretics and electrolytes in congestive heart failure, Am J Cardiol, 1990, 65(10):17E-21E
1 Roe, DA: Handbook on Drug and Nutrient Interactions, 5th edition, 1994.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 12(3): 533-540, 1975
4 Shaw D, et al. "Traditional remedies and food supplements: a 5-year toxicological study." Drug Safety, 1997; 17:342-56
4 Perharic L, Shaw D, Colbridge M, House I, Leon C, Murray V. Toxicological problems resulting from exposure to traditional remedies and food supplements. Drug Saf. 1994 Oct;11(4):284-94.
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Shintani S, Murase H, Tsukagoshi H, and Shiigai T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of two cases and review of the literature. Eur Neurol 32: 44-51, 1992
5 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998
5 Chan TY, Chan AY, Critchley JA. Hospital admissions due to adverse reactions to Chinese herbal medicines. J Trop Med Hyg. 1992 Aug;95(4):296-8.
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.