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Azathioprine
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• There are no known nutritional considerations, at this time.1
• Based on pharmacology: Laboratory studies have reported that constituents contained in shiitake mushroom may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.2
• Based on pharmacology: Laboratory studies have reported that constituents contained in picrorhiza root/rhizome may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.3
• Based on pharmacology: Laboratory studies have reported that constituents contained in larch arabinogalactan may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.4
• Based on pharmacology: Human and laboratory studies have reported that constituents contained in echinacea products may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.5
• Based on pharmacology: Studies have reported that cat's claw has immuno-stimulatory properties which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.6
• Based on pharmacology: Laboratory studies have reported that constituents contained in calendula flowers may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution when taking this supplement internally.7
• Based on pharmacology: Laboratory studies have reported that constituents contained in astragalus root may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.8
• Based on pharmacology: Studies have reported that arabinoxylane may increase immune function and therefore may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.9
• Based on pharmacology: Studies have reported that constituents contained in St. John's wort flowers may alter the function of certain cytochrome P450 isoenzyme systems which may change the effects of Azathioprine and possibly the dose needed for treatment. A case report found that St. John's wort decreased the effects of this medication. Use with caution.10
References1 N/A
2 Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.
2 Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.
3 Atal CK, et al. Immunomodulating Agents of Plant Origin. I: Preliminary Screening. J Ethnopharmacol. Nov1986;18(2):133-41.
3 Sharma ML, et al. Immunostimulatory Activity of Picrorhiza kurroa Leaf Extract. J Ethnopharmacol. Feb1994;41(3):185-92.
4 Hauer J, et al. Mechanism of Stimulation of Human Natural Killer Cytotoxicity by Arabinogalactan from Larix occidentalis. Cancer Immunol Immunother. 1993;36(4):237-44.
5 Vomel VT. The Effect of a Nonspecific Immunostimulant on the Phagocytosis of Erythrocytes and Ink by the Reticulohistiocyte System in the Isolated, Perfused Liver of Rats of Various Ages. Arzneim Forsch/Drug Res. 1984;34:691-95.
5 See DM, et al. In Vitro Effects of Echinacea and Ginseng on Natural Killer and Antibody-dependent Cell Cytotoxicity in Healthy Subjects and Chronic Fatigue Syndrome or Acquired Immunodeficiency Syndrome Patients. Immunopharmacology. 1997;35(3):229-35.
6 Wagner H, et al. The Alkaloids of Uncaria tomentosa and Their Phagocytosis-stimulating Action. Planta Med. 1995;5:419-23.
7 Wagner H, et al. Immunostimulating action of polysaccharides (heteroglycans) from higher plants. Arzneimittelforschung. 1985;35(7):1069-75.
8 Zhao KS, et al. Enhancement of the Immune Response in Mice by Astragalus membranaceus Extracts. Immunopharmacology. 1990;20(3):225-33.
8 Chu DT, et al. Immune Restoration of Local Xenogeneic Graft-versus-host Reaction in Cancer Patients in In-vitro and Reversal of Cyclophosphamide-induced Immune Suppression in the Rat in Vivo by Fractionated Astragalus membranaceus. Chung Hsi I Chieh Ho Tsa Chih. Jun1989;9:351-54.
9 Ghoneum M, et al. NK IMMUNOMODULATORY FUNCTION IN 27 CANCER PATIENTS BY MGN-3, A MODIFIED ARABINOXYLANE FROM RICE BRAN, 87th Annual Meeting of the American Association for Cancer Research. Washington DC. Apr1996.
9 Ghoneum M. ENHANCEMENT OF HUMAN NATURAL KILLER CELL ACTIVITY BY MODIFIED ARABINOXYLANE FROM RICE BRAN (MGN-3). INTERNATIONAL JOURNAL OF IMMUNOTHERAPY XIV(i). 1998;89-99.
10 Ruschitzka F, et al. Acute Heart Transplant Rejection Due to St. John's Wort. Lancet. Feb2000;355(9203): 548-49.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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