Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Pepcid may increase the risk for deficiencies in iron and zinc. Discuss a supplementation plan with your physician if there is long term use of the medication..1
• Pepcid may affect levels of folic acid and vitamin B12. Supplementation may be beneficial.2
• Use of alcohol and tobacco should be avoided.3
• Limit amounts of caffeine, including chocolate, coffee, tea, and sodas. Avoid supplements that contain caffeine.4
• Avoid cola, cocoa, guarana and mate with this medication due to their caffeine content.5
• Licorice may provide an added protectant effect if used together with H2 antagonists.6
• Acacia, Black mustard, Capsicum, Devil's Claw, Goldenseal,and Horseradish, all increase gastric acid and could therefore theoretically interact with Pepcid.7
References1 Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
1 Hakanson R, Persson P, Axelson J: Elevated serum gastrin after food intake or acid blockade evokes hypocalcemia, Regul Pept, 1990, 28(2):131-6.
1 Ghishan FK, Walker F, Meneely R, et al: Intestinal calcium transport - effect of cimetidine, J Nutr, 1981, 111(12): 2157-61.
1 Odes HS, Fraser GM, Krugliak P, et al: Effect of cimetidine on hepatic vitamin D metabolism in humans, 1990, 46(2):61-4.
1 Skikne BS, Lynch SR, Cook JD: Role of gastric acid in food iron absorption, Gastroenterology, 1981, 81(6):1068-71.
1 Sturniolo GC, Montino MC, Rossetto L, et al: Inhibition of gastric acid secretion reduces zinc absorption in man, J Am Coll Nutr, 1991, 10(4):372-5.
1 Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
2 Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
2 Force RW, Nahata MC: Effect of histamine-H2-Receptor antagonists on vitamin B12 absorption, Ann Pharmacother, 1992, 26(10):1283-6.
2 Russell RM, Golner BB, Krasinski SD, et al: Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid, J Lab Clin Med, 1988, 112(4):458-63.
3 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
3 Lieber, CS: Mechanisms of ethanol-drug-nutrition interactions. J Toxicol Clin Toxicol 1994;32(6):631-81.
3 Schurer-Maly CC, Varga L, Koelze HR, Halter F: Smoking and pH response to H2-receptor antagonists. Scand J Gastroenterol 1989; 24:1172-78.
4 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999.
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.