Abbokinase
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Vitamin K levels are important to the activity of this medication. The more vitamin K present, the greater the chance of blood clotting. Since the purpose of this medication is to lower clotting, foods high in vitamin K, such as spinach, cauliflower, brussel sprouts, and egg yolk should be limited or used with caution.1
• Consult with your pharmacist before taking supplemental CoEnzyme Q10, which has a similar chemical structure to vitamin K and may affect the effectiveness of this medication.2
• Avoid high dosages of vitamin A (over 10,000 IUs) or vitamin E (over 400 Ius).3
• More than 5 gms (5,000 mg) of vitamin C may reduce the absorption of this medication.4
• Absorption and activity of this medication may be altered by supplemental use of iron, magnesium, and zinc. Use of these minerals should be spaced at least two hours apart from the taking of this medication.5
• Please consult with your physician or pharmacist before taking nutritional supplements containing chondroitin sulfate.6
• More than 60 grams of onions (2 oz’s) may affect the activity of this drug.7
• Avoid excessive consumption of garlic, ginger, and avocado, due to their blood thinning properties.8
• Taking high doses of Grapefruit juice with this medication may interfere with drug therapy.9
• The following herbs may contribute to blood thinning and should not be used with this drug: Angelica, anise, arnica, asafoetida, bogbean, capsicum, celery, chamomile, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng (Panax), Gotu kola, horse chestnut, licorice, meadowsweet, papain, prickly ash, poplar, quassia, red clover, rue, and willow.10
• According to an Italian study, these herbs: Passionflower, hydroalcoholic extracts, Juniper and Verbena officinalis contain vitamin K and may interefere with drug therapy. Avoid their use together.11
References1 Weibert RT, Le DT, Kayser SR, et al. Correction of excessive anticoagulation with low-dose oral vitamin K. Ann Intern Med 1997;125:959-62
1 United States Pharmacopeia Drug Index (USPDI). 8th ed. Rockville, Md: US Pharmacopeial Convention, Inc; 1988:259-268.
1 Harris JE. Interaction of dietary factors with oral anticoagulants: Review and applications. J Am Dietet Assoc 1995;95:580-84 [review].
2 Harris JE. Interaction of dietary factors with oral anticoagulants: Review and applications. J Am Dietet Assoc 1995;95:580-84 [review].
2 Landbo C & Almdal TP [Interaction between warfarin and coenzyme Q10.] Ugeskr Laeger, 1998 May, 160:22, 3226-7.
2 Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;344:1372-73 [letter].
2 Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7; quiz 1228-30
2 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 286.
3 Wells, PS et al., Interactions of Warfarin with drugs and food. Ann. Int. Med. 1994, 121:676-683.
3 Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7; quiz 1228-30.
3 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 286.
4 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 286.
4 Wells, PS et al., Interactions of Warfarin with drugs and food. Ann. Int. Med. 1994, 121:676-683.
5 Wells, PS et al., Interactions of Warfarin with drugs and food. Ann. Int. Med. 1994, 121:676-683.
5 Harris JE. Interaction of dietary factors with oral anticoagulants: Review and applications. J Am Dietet Assoc 1995;95:580-84 [review].
5 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 286.
6 Chavez, M: Glucosamine sulfate and chondroitin sulfates. Hospital Pharmacy, 1997, 52(9): 1,275-1,285.
7 Menon, I.S. et al: Effect of onions on blood fibrinolytic activity. BMJ, 1968,3:351.
7 Pronsky, Z Food Medication Interactions, 11th edition, 1999
7 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 286.
8 Blickstein, D et al, "Warfarin antagonism by avocado", 1991, The Lancet 337:914-915.
8 Gadkari JV, Joshi VD. Effect of ingestion of raw garlic on serum cholesterol level, clotting time and fibrinolytic activity in normal subjects. J Postgrad Med 1991;37:128-31.
8 Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast-Reconst-Surg 1995;95:213.
9 Bartle, W. Grapefruit juice might still be factor in warfarin response (letter). American Journal of Health-System Pharmacy 1999; 56 (April 1): 676.
9 Sullivan D, et al. Grapefruit juice and the response to warfarin. American Journal of Health-System Pharmacy 1998; 55: 1581-1583.
10 Gadkari, et al. Effect of ingestion of raw garlic on serum cholesterol levels, clotting time and fibrinolytic activity in normal subjects. J Postgrad Med 1991;37:128-31.
10 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
10 Janetsky, K et al. Probably interaction between warfarin and ginseng. Am J Health-Syst Pharm 1997;54:692-93.
10 Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992;340:1136-39.
10 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
10 Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7; quiz 1228-30.
11 Argento A, Tiraferri E, Marzaloni M. [Oral anticoagulants and medicinal plants. An emerging interaction]. Ann Ital Med Int. 2000 Apr-Jun;15(2):139-43. Review. Italian.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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