Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid consuming excessive potassium in foods and supplements when taking this medication, including salt substitutes.1
• Alcohol intake should be limited.2
• This medication may contribute to a deficiency in zinc. Supplementation may be considered.3
• Avoid arginine in conjunction with these agents, because there is a potential for hyperkalemia to develop.4
• N-acetylcysteine may have additive blood pressure lowering effects with this medication.5
• Olive oil has been shown to reduce blood pressure, if used on a regular basis, antihypertensive drug dosage adjustment may need to be made.6
• CoQ10 may decrease blood pressure, therefore if combining this supplement with this medication, a dosage adjustment may need to be made.7
• Some herbs possess cardiac properties that may interact with the action of this drug and may result in an excessive lowering of blood pressure or increased side effects. Such herbs include: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, and shepherd's purse.8
• Avoid natural licorice products, Ginseng, and Ephedra (Ma huang) which may contribute to high blood pressure9
References1 Good CB, McDermott L, McCloskey B. Diet and serum potassium in patients on ACE inhibitors. JAMA 1995;274:538.
1 Burnakis TG & Mioduch HJ: Combined therapy with captopril and potassium supplementation. A potential for hyperkalemia. Arch Intern Med 1984; 144:2371-2372.
2 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
3 Golik A, Modai D, Averbukh Z, et al: Zinc metabolism in patients treated with captopril versus enalapril, Metabolism, 1990, 39(7): 665-7.
3 Golik A, Zaidenstein R, Dishi V, et al: Effects of captopril and enalapril on zinc metabolism in hypertensive s, J Am Coll Nutr, 1998, 17(1):75-8.
4 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
5 Ruiz FJ, Salom MG, Ingles AC, Quesada T, Vicente E, Carbonell LF.N-acetyl-L-cysteine potentiates depressor response to captopril and enalaprilat in SHRs. Am J Physiol. 1994 Sep;267(3 Pt 2):R767-72.
5 Suárez C, Del Arco C, Lahera V, Ruilope LM. N-Acetylcysteine potentiates the antihypertensive effect of angiotensin converting enzyme inhibitors [letter]. Am J Hypertens. 1995;8:859-861.
6 Ruiz-Gutierrez V, Muriana FJ, Guerrero A, Cert AM, Villar J. Plasma lipids, erythrocyte membrane lipids and blood pressure of hypertensive women after ingestion of dietary oleic acid from two different sources. J Hypertens 1996 Dec;14(12):1483-90
6 Baroni SS, Amelio M, Sangiorgi Z, Gaddi A, Battino M. Solid monounsaturated diet lowers LDL unsaturation trait and oxidisability in hypercholesterolemic (type IIb) patients. Free Radic Res. 1999 Apr;30(4):275-85.
6 Ferrara LA, Raimondi AS, d'Episcopo L, et al. Olive oil and reduced need for antihypertensive medications. Arch Intern Med 2000;160(6):837-842.
7 Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72.
8 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
8 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
8 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
9 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
9 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.