Sulfamethoxazole-Trimethoprim
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• This drug kills bacteria, including beneficial flora in the gut, which may affect digestion and/or elimination. Supplementation with acidophilus and/or bifidus may aid in restoring this beneficial flora.1
• Folate supplemention may be helpful with long term use.2
• Sulfamethoxazole in this drug may interfere with the absorption of calcium, vitamin B12 and magnesium with long term use of the medication.3
• Excess intake of vitamin C with this medication can cause crystals to form in the urine. Avoid high dose vitamin C supplements with this drug.4
• St. John's Wort can add to the risk of photosensitivity caused by sulfa drugs.5
References1 Bengmark S & Gianotti L: Nutritional support to prevent and treat multiple organ failure. World J Surg, 1996 May, 20:4, 474-81.
1 Cummings JH, Macfarlane G: Role of intestinal bacteria in nutrient metabolism, JPEN J Parenter Enteral Nutr, 1997, 21(6): 357-65.
1 Gorbach SL: Bengt E. Gustafsson Memorial Lecture, Function of the Normal Human Microflora, Scand J Infect Dis Suppl, 1986, 49:17-30.
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Kahn, SB, et al. Effects of trimethoprim on folate metabolism in man. Clinical Pharmacological Therapy 9: 550 - 560, 1968.
2 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 248-49, 251-52.
3 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 248-49, 250-51.
4 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 248-49, 250-51.
5 Seigers Cp, et al. Phototoxicity caused by hypericum. Nervehielkunde 12: 320 - 322, 1993.
5 Brockmoller J, et al. Hypericin and pseudohypericin: Pharmacokinetics and effects of photosensitivity in humans. Pharmacopychiatry (suppl. 2): 94 - 101, 1997.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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