Ampicillin
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Food can decrease absorption of the drug, take on an empty stomach 1 hr before or 2 hrs after a meal.1
• Amoxicillin may hinder the production of B vitamins and vitamin K. Supplementation may be beneficial with long term use of the drug.2
• Antibiotics kill bacteria, including beneficial flora in the gut, which may affect digestion and/or elimination. Supplementation with acidophilus or bifidus may aid in restoring beneficial flora.3
• Bromelain may increase ampicillin metabolism.4
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 336.
2 Hill MJ: Intestinal flora and endogenous vitamin synthesis, Eur J Cancer Prev, 1997, 6 (Suppl 1): S43-5.
2 Deguchi Y, et al: Comparative studies on synthesis of water-soluble vitamins among human species of Bifidobacteria, Argic Biol Chem, 1985, 19 (1):13-19.
2 Conly J and Stein K: Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials, Clin Invest Med, 1994, 17 (6):531-9.
3 Bengmark S & Gianotti L: Nutritional support to prevent and treat multiple organ failure. World J Surg, 1996 May, 20:4, 474-81.
3 Fuller R. Probiotics in human medicine. Gut 1991;32:439-42 [review].
3 Cummings JH, Macfarlane G: Role of intestinal bacteria in nutrient metabolism, JPEN J Parenter Enteral Nutr, 1997, 21(6): 357-65.
3 Gorbach SL: Bengt E. Gustafsson Memorial Lecture, Function of the Normal Human Microflora, Scand J Infect Dis Suppl, 1986, 49:17-30.
4 Neuvonen PJ et al., Comparative effect of food on absorption of ampicillin and pivampicillin. J Int Med Res 1977; 5: 71-76.
4 Tinozzi S, Venegoni A. Effect of bromelain on serum and tissue levels of amoxicillin. Drugs Exp Clin Res 1978;4:39-44.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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