Propecia
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Zinc, selenium, and the amino acids (glutamic acid, alanine and glycine) may be beneficial.1
• Avoid caffeine, alcohol and spicy foods.2
• Saw palmetto, nettle and pygeum are used to treat BPH and should not be used together with finasteride, there may be additive effects or side effects.3
• A plant source, beta-sitosterol has shown some evidence of helping improve some symptoms of benign prostatic hypertrophy. Since finasteride is also used for BPH, do not use both agents together without consulting a physician.4
• Cernilton, a rye pollen may improve symptoms of BPH, avoid using this with Propecia without consulting a physician. There may be additive effects.5
• Herbs with steroid components may increase side effects e.g. Sarsaparilla.6
References1 Webber, MM, "Selenium Prevents the Growth Stimulatory Effects of Cadmium on Human Prostatic Epithelium", Biochem Biophy res Commun 127(3):871-77, 1985
1 Fahim MS, Fahim Z, Der R, Harman J. Zinc treatment for reduction of hyperplasia of prostate. Fed Proc 1976;35(3):361.
1 Damrau F. Benign prostatic hypertrophy: amino acid therapy for symptomatic relief. J Am Geriatr Soc 1962;10:426-30.
2 Germano, Carl M.A.,R.D.,CNS, Nutritional Considerations in Benign Prostate Enlargement 1995.
3 Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon®) with finasteride in the treatment of benign prostate hyperplasia: A randomized international study of 1,098 patients. Prostate 1996;29:231-40.
3 Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia. A systematic review. JAMA 1998;280:1604-1609.
3 Braeckman J, Bruhwyler J, Vandekerckhove K, Géczy J. Efficacy and safety of the extract of Serenoa repens in the treatment of benign prostatic hyperplasia:Therapeutic equivalence between twice and once daily dosage forms. Phytotherapy Res 1997;11:558-63.
3 Koch E, Biber A. Pharmacological effects of sabal and urtica extracts as a basis for a rational medication of benign prostatic hyperplasia. Urologe 1994;334:90-95.
3 Metzker H, Kieser M, Hölscher U. Efficacy of a combined Sabal-Urtica preparation in the treatment of benign prostatic hyperplasia (BPH). Urologe [B] 1996;36:292-300
3 Bassi, P., et al, "Standardized Extract of Pygeum africanum in the Treatment of Benign Prostatic Hypertrophy", Minerva Urologica 39:45, 1987
3 Carilla, E., et al, "Binding of Permixon (Saw Palmetto Extract), A New Treatment For Prostatic Benign Hyperplsia", J Steroid Biochem 20 (1): 521-523, 1984
4 Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
4 Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of ß-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
5 Horii A, Iwai S, Maekawa M, Tsujita M. Clinical evaluation of Cernilton in the treatment of the benign prostatic hypertrophy. Hinyokika Kiyo 1985;31:739-45 (in Japanese).
5 Nakase K, Takenaga K, Hamanaka T, et al. Inhibitory effect and synergism of cernitin pollen extract on the urethral smooth muscle and diaphragm of the rat. Nippon Yakurigaku Zasshi 1988 Jun;91(6):385-92 [in Japanese].
5 Habib FK, Ross M, Buck AC, et al. In vitro evaluation of the pollen extract, cernitin T-60, in the regulation of prostate cell growth. Br J Urol 1990;66:393-97.
5 Suzuki T, Kurokawa K, Mashimo T, et al. Clinical effect of Cernilton in chronic prostatitis. Hinyokika Kiyo 1992;38:489-94 [in Japanese].
5 Buck AC, Cox R, Rees RW, et al. Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract, Cernilton. A double-blind, placebo-controlled study. Br J Urol 1990;66:398-404.
5 Dutkiewicz S. Usefulness of Cernilton® in the treatment of benign prostatic hyperplasia. Int Urol Nephrol 1996;28:49-53.
5 Maekawa M, Kishimoto T, Yasumoto R, et al. Clinical evaluation of Cernilton on benign prostatic hypertrophy—a multiple center double-blind study with Paraprost. Hinyokika Kiyo 1990;36:495-516 [in Japanese].
5 Becker H, Ebeling L. Conservative therapy of benign prostatic hyperplasia (BPH) with Cernilton. Urologe (B) 1988;28:301-306 [in German].
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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