Promethazine Hydrochloride
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Promethazine may increase nutritional requirements for riboflavin, and supplementation may be beneficial. For optimal benefit, a B-Complex supplement is recommended.1
• Avoid alcohol while taking this medication.2
• Promethazine may deplete coenzyme Q-10 with long term use of the medication.3
• Phenylalanine may make tardive dyskinesia worse when taken with phenothiazines.4
• Promethazine may increase Yohimbe toxicity. Do not take this combination.5
References1 Pinto JT, Rivlin RS, Drugs that promote renal excretion of riboflavin, 1987 Drug Nutrient Interactions 5:143-151.
1 Tinguely D, Jonzier M, Schopf J, et al. Determination of Compliance with Riboflavin in an Antidepressive Therapy. Arzneimittelforschung, 1985, 35(2): 536-8
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 255.
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Folkers K. Basic chemical research on coenzyme Q10 and integrated clinical research on therapy of diseases. As cited in Lenaz G (ed.). Coenzyme Q. New York: John Wiley and Sons, 1985.
3 Kishi T, et al, "Inhibition of Myocardial Respiration by Psychotherapeutic Drugs an Prevention by Coenzyme Q" Biomedical and Clinical Aspects of Coenzyme Q, Yamamura Y, Folkers K and Ito Y, eds Elsevier/North-Holland Biomedical Press: Amsterdam, 1980, vol 2, 139-54.
4 Mosnik DM, Spring B, Rogers K, and Baruah SL. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 16(2): 136-146, 1997
4 Gardos G, Cole JO, Matthews JD, Nierenberg AA, Dugan SJ. The acute effects of a loading dose of phenylalanine in unipolar depressed patients with and without tardive dyskinesia. Neuropsychopharmacology. 1992 Jun;6(4):241-7.
5 DeSmet PAGM, Smeets OSNM. "Potential risks of health food products containing yohimbe extracts," Br. Med. J., 309:958, 1994.
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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