Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Cimetidine may increase the risk for deficiencies in calcium, magnesium, iron, zinc, and vitamin D. Discuss a nutritional supplement plan with your physician or pharmacist.1
• Noted nutritional deficiencies exist between Cimetidine, and the nutrients folic acid and vitamin B-12. Supplementation is recommended. For optimal benefit, a B-Complex supplement is recommended.2
• Avoid alcohol and tobacco, both of which affect Cimetidine.3
• Limit caffeine intake. This includes coffee, tea, sodas, chocolate, and caffeine-containing nutritional supplements.4
• Avoid black tea, cocoa, coffee, cola nut, guarana, green tea and mate because the caffeine can interfere with H2 antagonists.5
• Licorice may theoretically provide an added protective effect with H2 antagonists.6
References1 Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
1 Hakanson R, Persson P, Axelson J: Elevated serum gastrin after food intake or acid blockade evokes hypocalcemia, Regul Pept, 1990, 28(2):131-6.
1 Ghishan FK, Walker F, Meneely R, et al: Intestinal calcium transport - effect of cimetidine, J Nutr, 1981, 111(12): 2157-61.
1 Odes HS, Fraser GM, Krugliak P, et al: Effect of cimetidine on hepatic vitamin D metabolism in humans, 1990, 46(2):61-4.
1 Skikne BS, Lynch SR, Cook JD: Role of gastric acid in food iron absorption, Gastroenterology, 1981, 81(6):1068-71.
1 Sturniolo GC, Montino MC, Rossetto L, et al: Inhibition of gastric acid secretion reduces zinc absorption in man, J Am Coll Nutr, 1991, 10(4):372-5.
2 Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
2 Force RW, Nahata MC: Effect of histamine-H2-Receptor antagonists on vitamin B12 absorption, Ann Pharmacother, 1992, 26(10):1283-6.
2 Russell RM, Golner BB, Krasinski SD, et al: Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid, J Lab Clin Med, 1988, 112(4):458-63.
3 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
3 Lieber, CS: Mechanisms of ethanol-drug-nutrition interactions. J Toxicol Clin Toxicol 1994;32(6):631-81.
3 Schurer-Maly CC, Varga L, Koelze HR, Halter F. Smoking and pH response to H2-receptor antagonists. Scand J Gastroenterol 1989;24:1172-78.
4 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.