Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Calcium and vitamin D may interfere with calcium channel blockers. Consult a pharmacist regarding their use together.1
• Avoid grapefruit juice with this medication.2
• Avoid alcohol3
• Avoid natural Licorice products, ginseng, and ephedra (ma huang) which may interfere with this medication.4
• The following herbs may have diuretic properties, which may increase the effects of this medication and may possibly lead to an excessive lowering of blood pressure: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain.5
• St. John’s Wort may interact with some calcium channel blockers due to the use of similar pathways (eg. cytochrome P450) to metabolize the drugs and herb.6
• These herbs have cardiac properties which may increase cardiac side effects of this medication: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot7
References1 Kuhn M and Schriger DL. Low-dose calcium pretreatment to prevent verapamil-induced hypotension. Am Heart J 124: 231-232, 1992.
1 Luscher TF, Noll G, Sturmer T, et al. Calcium gluconate in severe verapamil intoxication. N Engl J Med 330: 718-720, 1994.
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Fuhr U, Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. Drug Saf 1998 Apr; 18(4): 251-72.
3 Reference not available.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 Yue QY, Bergquist C, GerdÈn B. Safety of St John's wort (Hypericum perforatum). Lancet 2000;355(9203).
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
7 Blumenthal M, Busse WR, Goldberg A, et al, eds. The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 161-62.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.