Chlorpromazine
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Take with food or milk to decrease stomach upset. Dilute concentrated forms before use.1
• Chlorpromazine may deplete Co-Q-10 levels in the body. Supplementation may be helpful.2
• Vitamin B2 or riboflavin may be depleted with phenothiazines like Chlorpromazine.3
• Take magnesium supplements or antacids separated by at least 2 hours from the drug.4
• Chlorpromazine may reduce the absorption of vitamin B12, monitor with long term use of the drug.5
• Vitamin E may be helpful in reducing the incidence of tardive dyskinesia associated with phenothiazine use.6
• Avoid alcohol intake.7
• Avoid phenylalanine supplements while taking phenothiazines because the risk of tardive dyskinesia may increase.8
• Avoid tobacco, it may increase metabolism of the drug.9
• Avoid caffeine with phenothiazines because the effect of the drug could be changed if caffeine is taken within 40 minutes of the drug.10
• Milk thistle contains silymarin, which may protect the liver against phenothiazine damage with long term use.11
• Ginkgo may reduce some side effects of phenothiazines.12
• Evening Primrose Oil may increase seizure potential if used together with phenothiazines.13
• Yohimbe toxicity is increased if used together with chlorpromazine.14
• The sedative/hypnotic effects of Yerba Mansa will increase sedative side effects of chlorpromazine.15
• Cocoa, cola, guarana and mate all have caffeine and this may interfere with phenothiazines.16
• Kava may increase dystonia if used together with phenothiazines.17
• The CNS depressant tendency of: devil's claw, lemonbalm, ma huang, meadowsweet, mullein, peppermint, pokeroot, European poplar, prickly ash, queen of the meadow and sassafras can potentiate CNS side effects of the phenothiazines.18
• Avoid alfalfa with this medication due to the increased risk of photosensitivity with this combination.19
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Folkers K. Basic chemical research on coenzyme Q10 and integrated clinical research on therapy of diseases. As cited in Lenaz G (ed.). Coenzyme Q. New York: John Wiley and Sons, 1985
2 Kishi T, et al, Inhibition of Myocardial Respiration by Psychotherapeutic Drugs and Prevention by Coenzyme-Q, Biomedical and Clinical Aspects of Coenzyme Q, Yamamura Y, Folkers K, and Ito Y, eds, Elsevier/North Holland Biomedical Press: Amsterdam, 1980, Vol 2, 139-54.
3 Bell, IR, Edman JS, Morrow FD, et al, B1,B2, and B6 Augmentation of Tricyclic Antidepressant Treatment in Geriatric Depression with Cognitive Dysfunction, J Amer Coll Nutr, 1992, 11(2):159-63.
3 Pinto, J, Huang YP, and Rivlin RS, Inhibition of Riboflavin Metabolism in Rat Tissues by Chlorpromazine, Imipramine, and Amitriptyline, J Clin Invest, 1981, 67(5):1500-6
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Adler LA, et al. Long term treatment effects of vitamin E for tardive dyskinesia. Biol Psychiatry 43: 868-872, 1998
6 Adler LA, et al. Vitamin E treatment of tardive dyskinesia. Am J Psychiatry 150: 1405-1407, 1993.
6 Inada T: [Recent research trends in diagnosis, treatment, and prevention of drug-induced extrapyramidal symptoms seen in psychiatric patients.] Nihon Shinkei Seishin Yakurigaku Zasshi, 1996 Oct, 16:5, 181-5.
7 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 Pronsky, Z Food Medication Interactions, 11th edition, 1999
8 Mosnik DM, Spring B, Rogers K, and Baruah SL. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 16(2): 136-146, 1997.
8 Richardson MA. Amino acids in psychiatric disease. Washington, DC: American Psychiatric Press, 1990.
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
10 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
11 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
11 Palasciano G, et al. The effect of silymarin on plasma levels of malondialdehyde in patients receiving long term treatment with psychotropic drugs. Curr Ther Res 55: 537-545, 1994
12 Liu P, et al. Combined use of Ginkgo biloba extracts on efficacy and adverse reactions of various antipsychotics. Zhongguo Linchuang Yaolixue Zaxhi 13(4): 193-198, 1997
13 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
14 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
15 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
16 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
17 Schelosky L, et al. Kava and dopamine antagonism. J Neurol Neurosurg Psych 58(5): 639-640, 1995
18 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
18 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
19 Brown R. Potential interactions of herbal medicines with antipsychotics, antidepressants and hypnotics. European Journal of Herbal Medicine 1997;3:25-8.
|
 Want more special reports like this e-mailed to you when they're available? Click here for free e-mail alerts.
Share this Special Report by linking to it
Copy and paste the following HTML code into any web page:
Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
|
