Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• This medication may affect the proper absorption of beta carotene, iron and vitamin B12. Consult with your pharmacist about supplementation.1
• Alcohol intake should be limited.2
• Beta-carotene - eat dark green and orange-yellow vegetables and supplement 25,000 IU of beta-carotene per day to replenish this nutrient in the body.3
• Vitamin B12 and Folic Acid - Take 1,000 mcg of vitamin B12 and 400 mcg of Folate daily to avoid nutrient depletion caused by the drug’s ability to inhibit absorption. Nutrient depletion can lead to high homocysteine blood levels and anemia.4
• Cranberry Juice may prevent vitamin B12 deficiency by aiding the absorption of vitamin B12 being received from foods high in this nutrient.5
• Prevacid may interact with St. John's Wort to increase the risk of photosensitivity.6
References1 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
1 Graedon J, Graedon T: The People’s Guide to Deadly Drug Interactions, 1995, p. 94.
1 Koop H, Bachem MG. Serum iron, ferritin, and vitamin B12 during prolonged omeprazole therapy. J Clin Gastroenterol 1992;14:288-92.
1 Schenk BE, Festen HP, Kuipers EJ, et al. Effect of short-and long-term treatment with omeprazole on the absorption and serum levels of cobalamin. Aliment Pharmacol Ther 1996;10:541-45.
1 Bellou A, Aimone-Gastin I, De Korwin JD, et al: Colbalamin deficiency with megaloblastic anemia in one s under long-term omeprazole therapy, J Intern Med, 1996, 240(3): 161-4.
1 Saltzman JR, Kemp JA, Golner BB, et al: Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption, J Am Coll Nutr, 1994, 13 (6):584-91.
1 Tang G, Serfaty-Lacronsniere C, Camilo ME, Russell RM. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-26.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Tang G, Serfaty-Lacronsniere C, Camilo ME, Russell RM. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr 1996;64:622-6.
4 Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458-63.
4 Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J Am Coll Nutr 1994;13:584-9
5 Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J Am Coll Nutr 1994;13:584-91
6 Mirossay A, Mirossay L, Tothova, et al. Potentiation o hypericin an dhypocrellin-induced phototoxicity by omeprazole. Phytomedicine 6(5): 311 - 317, 1999.
6 Seigers Cp, et al. Phototoxicity caused by hypericum. Nervehielkunde 12: 320 - 322, 1993.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.