Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Take with food to avoid stomach upset.1
• Avoid alcohol.2
• Long term NSAID use may cause kidney impairment and increased potassium levels. Potassium is also a gastrointestinal irritant. Do not supplement potassium without consulting a physician.3
• Avoid large doses of vitamin E and NSAID's together, there may be a possible risk of increased bleeding.4
• Avoid ginkgo with NSAID's, there may be an increased risk of bleeding with long term use.5
• Licorice may protect the stomach from irritation associated with long term NSAID use.6
• Avoid these herbs with NSAID's like Toradol due to their potential to increase bleeding times: dong quai, feverfew, garlic, ginger, horse chestnut, and red clover.7
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Bailie GR. Acute renal failure. In Applied Therapeutics: The Clinical Use of Drugs, 6th ed. Vancouver, WA: Applied Therapeutics, 1995, 29-33.
4 Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.
5 Rosenblatt M and Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 336(15): 1108, 1997.
5 Lamant V, Mauco G, Braquet P, Chap H, Douste-Blazy L. Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochem Pharmacol 1987; 36: 2749-52
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.