Clozaril
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Avoid alcohol1
• Avoid caffeine found in coffee, tea, and other beverages and supplements with clozaril. There may be increased effects or adverse reactions.2
• Avoid ipriflavone with clozaril. There may be increased side effects or toxicity due to the inhibition of cytochrome P-450 pathway by ipriflavone.3
• Avoid St. John's Wort with clozaril. There may be an increased risk of side effects or adverse reactions.4
• Avoid cola, cocoa, guarana and mate with clozaril due to their caffeine content.5
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49(1):59-63.
2 Carrillo JA, Herraiz AG, Ramos SI, Benitez J. Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients. J Clin Psychopharmacol. 1998 Aug;18(4):311-6.
3 Monostory K, Vereczkey L, Levai F, Szatmari I. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol. 1998 Feb;123(4):605-10.
3 Monostory K, Vereczkey L. Interaction of theophylline and ipriflavone at the cytochrome P450 level. Eur J Drug Metab Pharmacokinet. 1995 Jan-Mar;20(1):43-7.
4 De Smet PA and Touw DJ. Safety of St. John's wort. Lancet 355 (9203): 575- 576, 2000.
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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