Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Take during the first part of a meal.1
• Precose may reduce the absorption of iron. Monitor levels periodically on long term drug therapy.2
• Do not take this medication with intestinal absorbents, like charcoal or digestive enzymes, it may reduce the effect of the drug.3
• Avoid the supplement ipriflavone with precose, it may have additive hypoglycemic effects.4
• It may be advisable to avoid high doses of vitamin E with this medication due to the possibility of increased hypoglycemia.5
• Avoid L-carnitine, chromium and coenzyme Q-10 with oral hypoglycemic agents because there could be an additive hypoglycemic effect.6
• Avoid or limit alcohol use with this medication.7
• Potatoes can interfere with blood sugar levels and precose dosage may require adjustment.8
• The following herbs may potentiate the hypoglycemic effects of this drug: Aloes, Bilberry, Bitter melon, Blueberry, Burdock, Celery, Cornsilk, Dandelion, Fenugreek, Garlic, Ginseng, Gymnema, Juniper, Nettle, and Onion plant.9
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Monostory K, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 123(4): 605-610, 1998.
5 Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
6 Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
6 Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Human Hypertens 13: 203-208, 1999.
6 Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr. 1997 Oct;16(5):404-10.
7 Pronsky, Z Food Medication Interactions, 11th edition, 1999
8 Gannon MC, et al. Diabetes Care 1993;16:874.
8 The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
9 Brinker F. Herb contraindications and drug interactions, 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998
9 Bever BO and Zahnd GR. Plants with oral hypoglycemic action. Q J Crude Drug Res 17: 139-196, 1979.
9 Mathew PT and Augusti KT. Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes mellitus- a preliminary report. Indian J Physiol Pharmacol 19: 213-217, 1975.
9 Manickam M, Ramanathan M, Jahromi MA, et al. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 60: 609-610, 1997.
9 Stern E. Successful use of Atriplex halimus in the treatment of type 2 diabetic patients: a preliminary study. Zamenhoff Medical Center, Tel Aviv, 1989
9 Khan AK, Akhtar S, and Mahtab H. Treatment of diabetes mellitus with Coccinia indica. BMJ 280: 1044, 1980.
9 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.