Allopurinol
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Consume adequate fluids, unless otherwise directed to keep urine alkaline.1
• Allopurinol may contribute to iron depletion, and iron supplementation may be beneficial.2
• Take with food or milk to reduce stomach upset.3
• Avoid large doses of vitamin C, this may contribute to an increased risk of kidney stones with allopurinol.4
• Allopurinol may theoretically increase the length of action of anticoagulant herbs, based on its known interaction with warfarin. These herbs include : Angelica, anise, arnica, asafoetida, bogbean, boldo, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng (Panax), horse chestnut, licorice, meadowsweet, prickly ash, passionflower, poplar, quassia, red clover, turmeric, and willow.5
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Park GD, Berlinger WG, Spector R, Kitt TM, Tsalikian E: Sustained reductions in oxypurinol renal clearance during a restricted diet, Clinical Pharmacol Ther, 1987; 41:616-621.
2 Lin YW, Okazaki S, Hamahata K, Watanabe K, Usami I, Yoshibayashi M, Akiyama Y, Kubota M. Acute pure red cell aplasia associated with allopurinol therapy. Am J Hematol. 1999 Jul;61(3):209-11.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Brinker, Francis: Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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