Propoxyphene-N/APAP
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• The use of alcohol should be avoided. It can intensify the effects of Propoxyphene.1
• N-acetyl cysteine may protect against liver damage caused by acetaminophen overdose. Long term use of this medication may cause liver problems. Discuss supplementation with a pharmacist or physician.2
• Over 3 grams of vitamin C can reduce acetaminophen clearance.3
• Foods high in carbohydrates, pectin and vegetables like broccoli, brussel sprouts, cabbage, etc. can interfere with acetaminophen absorption.4
• Herbs with sedative properties may intensify the effects of this drug, and should not be used at the same time. These herbs include: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa.5
References1 Graedon J, Graedon T: The People’s Guide to Deadly Drug Interactions, 1995, 234.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Vale JA, Proudfoot AT. Paracetamol (acetaminophen) poisoning. Lancet 1995;346:547-52
3 Houston JB, Levy G. Drug biotransformation interactions in man. VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:121-21.
4 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 2.
5 Brinker, Francis: Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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