Paxil
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Alcohol should not be combined with Paxil.1
• Foods and supplements containing tryptophan or 5-HTP should be avoided in combination with Paxil.2
• Herbs that may interact with Paxil to increase sedation include:calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa3
• Melatonin may help improve sleep used together with these agents in depressed individuals. Discuss use of the supplement with a pharmacist.4
References1 PDR (Physicians Desk Reference). 49th Edition. Medical Economics Co. Montvale, NJ. 1995.
1 Threlkeld DS, ed. Central Nervous System Drugs, Antidepressants, Selective Serotonin Reuptake Inhibitors. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparison, Apr 1997.
1 Naranjo CA, Pouos CX, Bremner KE, Lanctot KL. Fluoxetine attenuates alcohol intake and desire to drink. Int Clin Psychopharmacol 1994;9:163-72.
2 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 379.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996:21,45,63,282.
3 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998.
3 Demott K. St. John’s wort tied to serotonin syndrome. Clinical Psychiatry News 1998;26:28.
3 Gordon JB. SSRIs and St. John’s wort: possible toxicity? Am Fam Physician 1998;57:950.
3 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
4 Dolberg OT, Hirschmann S, Grunhaus L. "Melatonin for the treatment of sleep disturbances in major depressive disorder." Am J Psychiatry, Aug. 1998; 155(8):1119-121.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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