Enalapril
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• Avoid consuming excessive potassium in foods and supplements when taking this drug. Ask your physician or pharmacist for more information regarding electrolyte balance.1
• The use of alcohol should be avoided or limited.2
• This medication may contribute to zinc deficiency. Supplementation may be considered with long term use.3
• Avoid iron with this medication due to possible decreased drug absorption caused by iron.4
• Several studies done with olive oil, have shown it can reduce blood pressure. The dosage of antihypertensive medications may need to be reduced when olive oil is consumed on a regular basis.5
• CoQ10 may reduce blood pressure. If it is taken with this medication, a dosage adjustment may need to be made.6
• Some herbs possess diuretic properties that may intensify the action of this drug and may lead to excessive lowering of blood pressure. Such herbs include: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, and Vervain7
• Avoid natural licorice products, ginseng, and ephedra (ma huang), which may contribute to high blood pressure.8
• Topical capsaicin may increase the cough associated with using ACE inhibitors.9
• Avoid yohimbe with this drug, it could increase side effects or cause adverse reactions.10
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
1 Good CB, McDermott L, McCloskey B. Diet and serum potassium in patients on ACE inhibitors. JAMA 1995;274:538.
1 Burnakis TG & Mioduch HJ: Combined therapy with captopril and potassium supplementation. A potential for hyperkalemia. Arch Intern Med 1984; 144:2371-2372.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
3 Golik A, Modai D, Averbukh Z, et al: Zinc metabolism in patients treated with captopril versus enalapril, Metabolism, 1990, 39(7): 665-7.
3 Golik A, Zaidenstein R, Dishi V, et al: Effects of captopril and enalapril on zinc metabolism in hypertensive patients, J Am Coll Nutr, 1998, 17(1): 75-8.
4 Schaefer JP, Tam Y, Hasinoff BB, Tawfik S, Peng Y, Reimche L, Campbell NR. Ferrous sulphate interacts with captopril. Br J Clin Pharmacol. 1998 Oct;46(4):377-81.
4 Campbell NR, Hasinoff BB. Brit J Clin Pharmacol 1991 Mar;31(3):251-255.
5 Ruiz-Gutierrez V, Muriana FJ, Guerrero A, Cert AM, Villar J. Plasma lipids, erythrocyte membrane lipids and blood pressure of hypertensive women after ingestion of dietary oleic acid from two different sources. J Hypertens 1996 Dec;14(12):1483-90
5 Baroni SS, Amelio M, Sangiorgi Z, Gaddi A, Battino M. Solid monounsaturated diet lowers LDL unsaturation trait and oxidisability in hypercholesterolemic (type IIb) patients. Free Radic Res. 1999 Apr;30(4):275-85.
5 Ferrara LA, Raimondi AS, d'Episcopo L, et al. Olive oil and reduced need for antihypertensive medications. Arch Intern Med 2000;160(6):837-842.
6 Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72.
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
8 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
8 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
9 Hakas JF. Topical capsaicin induces cough in patient receiving ACE inhibitor. Ann Allergy 1990: 65:322
9 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
10 Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. , 1996.
10 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
10 Facts and Comparisons, The Review of Natural Products , Wolters Kluwer Co., 2000
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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