Lipids from camel milk exhibit in vitro anti-inflammatory properties
11/27/2019 // Evangelyn Rodriguez // Views

In this study, researchers from Oman, the UAE, and the U.K. investigated the effect of camel milk on glycated protein-mediated macrophage inflammation. The results of their study were published in the journal Functional Foods in Health and Disease.

  • Camel milk is known for its anti-diabetic and health-promoting properties.
  • The lipids in camel milk have also been reported to have anti-inflammatory effects. However, the mechanism behind these effects are not well-studied.
  • To determine how total lipids (TL) and total fatty acids (TFA) from camel milk can affect diabetic inflammation, the researchers used an in vitro model of differentiated THP-1 (dTHP-1) cells stimulated with glycated serum albumin (gBSA). These cells were pre-treated with TL or TFA before gBSA.
  • Using GC-MS, the researchers found that TL is 96 percent triacylglycerol (TAG) while TFA is 65 percent saturated fatty acids and 35 percent unsaturated fatty acids.
  • Both TL and TFA decreased gBSA-induced secretion of pro-inflammatory cytokines like tumor necrosis factor-a (TNF-a) and interleukin-1B (IL-1B).
  • TL demonstrated the ability to regulate the expression of p50/p65 subunits of nuclear factor-kappa B (NF-kB) while concomitantly increasing the expression of regulatory cytokines like IL-10, IL-1 receptor antagonist (IL-1Ra) and cluster of differentiation 163 (CD163)-shifting cells toward an M2 macrophage phenotype.
  • In addition, TL regulated the expression of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome subunit and its regulator, ten-eleven translocation-2 (TET-2).

Based on these results, the researchers concluded that camel milk lipids can regulate gBSA-induced macrophage inflammation in vitro by controlling the expression of key inflammatory regulators like NF-kB and NLRP3 inflammasome subunit.

Journal Reference:

Al-Nasseri RH, Al-Ruqashi H, Al-Sabahi J, Al-Harrasi A, Kenekanian A, Banerjee Y, Morris K, Hassan N. LIPIDS DERIVED FROM CAMEL MILK REGULATE NLRP3 INFLAMMASOME-DEPENDENT INFLAMMATORY RESPONSES IN HUMAN MACROPHAGES. Functional Foods in Health and Disease. 2019;9(4):224. DOI: 10.31989/ffhd.v9i4.567

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.