A closer look at the immunostimulatory effects of ginseng berry polysaccharides
04/15/2020 // Evangelyn Rodriguez // Views

South Korean researchers investigated the effects of polysaccharides from ginseng berry on the activation of natural killer (NK) cells and the inhibition of tumors. Their findings were published in The American Journal of Chinese Medicine.

  • Ginseng root is used in traditional Chinese medicine for the enhancement of immune system function.
  • To explore the immunostimulatory effects of ginseng berry, the researchers isolated a crude polysaccharide (GBPP) and used gel filtration chromatography to obtain three more fractions, namely, GBPP-I, GBPP-II and GBPP-III.
  • GBPP-I consisted of mainly galactose (46.9 percent) and arabinose (27.5 percent) and showed a high dose-dependent anti-complementary activity.
  • GBPP-I stimulation of murine peritoneal macrophages enhanced interleukin (IL)-6, IL-12 and tumor necrosis factor (TNF)-a production.
  • Meanwhile, oral administration of GBPP-I significantly increased NK cell cytotoxicity in YAC-1 tumor cells and production of granzyme B.
  • Prophylactic intravenous and oral administration of GBPP-I significantly and dose-dependently inhibited lung metastatic activity in B16-BL6 melanoma cells.
  • On the other hand, depletion of NK cells after the injection of rabbit anti-asialo GM1 partially abolished the inhibitory effect of GBPP-I on lung metastasis. This suggested that NK cells play an important role in anti-cancer effects.

Based on these findings, the researchers concluded that GBPP-I has strong-immune-enhancing activity and can prevent cancer metastasis via activation of NK cells and other immune-related cells.

Journal Reference:

Lee DY, Park CW, Lee SJ, Park HR, Seo DB, Park JY, Park J, Shin KS. IMMUNOSTIMULATING AND ANTIMETASTATIC EFFECTS OF POLYSACCHARIDES PURIFIED FROM GINSENG BERRY. The American Journal of Chinese Medicine. 2019;47(04):823–839. DOI: 10.1142/s0192415x19500435

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to NaturalNews.com (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.