Carried out by researchers from Korea Food Research Institute and the University of Science & Technology in South Korea, the study looked at the effects of five-flavor fruit extract on fatty liver both in animal and lab tests. The research team hypothesized that fatty liver could be reduced by the hypolipidemic activity of five-flavor fruit extract through the inhibition of histone acetyltransferase (HAT).
To test this hypothesis, the team treated HepG2 cells -- human liver cancer cell lines -- with five-flavor fruit extract. The results revealed that the treatment with five-flavor fruit extract reduced oleic acid-induced lipid accumulation. In addition, it also attenuated HAT activity.
The team also conducted in vivo tests, in which they fed obese mice either with a low-fat diet or Western diet, known to be high in fat. Then, they supplemented the obese mice with five-flavor fruit extract. The researchers found that supplementing with the extract reduced the body and liver weights of mice. The five-flavor fruit extract treatment also reduced liver fat accumulation and lipogenic gene expression and inhibited HAT activity.
Based on these findings, the research team concluded that five-flavor fruit extract may be used to prevent fatty liver disease.
Today, fatty liver disease affects almost one-third of adults in the U.S. and is one of the leading contributors to liver failure. (Related: Negative effects of acetaminophen may be reduced with magnolia berry.)
In addition to taking five-flavor fruit extract, you can also lower your risk of fatty liver disease by:
The five-flavor plant is a vine that bears purple-red berries. These berries have five tastes: sweet, salty, bitter, pungent, and sour – hence the name "five-flavor" fruit. This fruit-bearing vine is used for many health benefits. In traditional Chinese medicine, it is used to enhance heart, lung, and kidney health. Scientific evidence also shows that it can be used for the following health conditions:
Five-flavor fruit is available in dried form or as juice. It is also sold as a supplement in various forms: dried powder, pills, extracts, and elixirs.