Exploring the anti-carcinogenic potential and biosafety of Indian propolis
04/09/2020 // Evangelyn Rodriguez // Views

Researchers at Bharati Vidyapeeth University in India extracted and standardized Indian propolis (IP) with respect to selected markers so they could evaluate its anti-cancer activity and biosafety in vitro and in vivo. The results of their study were published in the Journal of Ayurveda and Integrative Medicine.

  • Propolis from apiculture has a wide range of medicinal properties, thanks to its abundance in phytonutrients, such as polyphenols, flavonoids and the anti-cancer agent, caffeic acid phenethyl ester (CAPE).
  • For their analysis, the researchers extracted, optimized and standardized IP using a newly developed and validated liquid chromatography method that simultaneously estimates caffeic acid, apigenin, quercetin and CAPE content.
  • Then, they screened the standardized ethanolic extract of IP (EEIP) for in vitro cytotoxicity, anti-carcinogenic effect (against Dalton’s Lymphoma ascites (DLA) cells), hemolytic effect and pesticidal potential.
  • The researchers found that EEIP contains more flavonoids, polyphenolic compounds and all the selected markers except for caffeic acid, than IP extracts obtained using other solvents.
  • EEIP also showed better anti-cancer activities than CAPE on MCF-7 and HT-29 cells in vitro.
  • In vivo, EEIP had better anti-carcinogenic effects against DLA than 5-fluorouracil. It also proved to be non-hemolytic.

Based on these findings, the researchers concluded that the standardized EEIP is a safe anti-carcinogenic agent that can be further developed into a natural anti-cancer medicine.

Read the full study at this link.

Journal Reference:

Kapare H, Lohidasan S, Sinnathambi A, Mahadik K. STANDARDIZATION, ANTI-CARCINOGENIC POTENTIAL AND BIOSAFETY OF INDIAN PROPOLIS. Journal of Ayurveda and Integrative Medicine. 2019;10(2):81–87. DOI: 10.1016/j.jaim.2017.06.003

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