Salvia miltiorrhiza found to be toxic to multi-drug resistant cancer cells
06/20/2019 // Michelle Simmons // Views

A study published in the journal The American Journal of Chinese Medicine examined the cytotoxicity and the biological mechanisms of red sage (Salvia miltiorrhiza) on diverse resistant and sensitive cancer cell lines. The study was conducted by researchers from the Johannes Gutenberg University Mainz and the Institute of Biotechnology and Drug Research in Germany.

  • Red sage is a popular Chinese herb that has numerous therapeutic activities, including anticancer effects.
  • In this study, the researchers investigated the anticancer effects of red sage root extract.
  • The results suggested that red sage root extract can induce cancer cell death.
  • The researchers noted the increased cleavage of caspase 3, 7, 9, and poly ADP-ribose polymerase (PARP), which confirmed the induction of the intrinsic apoptotic pathway.
  • In addition, mitogen-activated protein kinases (MAPK) were phosphorylated and nuclear P65 was downregulated upon red sage root extract treatment.
  • They associated the expression of encoding genes with diverse functions with the cellular response to cryptotanshinone, one of the main constituents of red sage root extract.

Based on these findings, the researchers concluded that red sage root extract exhibits significant cytotoxicity against various sensitive and resistant cancer cells and activates the intrinsic apoptotic pathway.

Learn more about herbal medicines that have anticancer effects like red sage at

Journal Reference:

Wu CF, Bohnert S, Thines E, Efferth T. CYTOTOXICITY OF SALVIA MILTIORRHIZA AGAINST MULTIDRUG-RESISTANT CANCER CELLS. The American Journal of Chinese Medicine. 24 May 2016;44(4):871-894. DOI: 10.1142/S0192415X16500488

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.