Resveratrol and exercise found to attenuate fracture risk in mice with Alzheimer’s disease
06/06/2019 // Michelle Simmons // Views

A study published in the journal BMC Complementary and Alternative Medicine looked at the effect of resveratrol and exercise on age-related bone fractures in mice. The study was carried out by researchers at Midwestern University and Auburn University.

  • Osteoporosis and Alzheimer’s disease, which are progressive diseases that affect older adults, are associated with increased fracture risk.
  • In the study, the researchers hypothesized that resveratrol and exercise can reduce the risk of bone fractures in mice with Alzheimer’s disease and age-matched wild type mice.
  • To test the hypothesis, they treated mice with resveratrol or exercise or a combination of the two for four months.
  • Exercise training was performed on a treadmill at 15 meters (m) for 45 minutes every day, five times a week.
  • Resveratrol was administered at 4 grams per kilogram (g/kg) in the form of pellets.
  • Mice with Alzheimer’s disease exhibited signs of diminished bone quality and fracture, increasing their risk for limb bone fracture compared to wild type controls.
  • The results showed that treatment with both resveratrol and exercise improved indicators of fracture resistance and bone quality in mice with Alzheimer’s disease.

In sum, the findings suggested that that resveratrol and exercise can enhance bone strength and resistance to fracture, indicating their potential in Alzheimer’s disease-related fracture risk.

For more studies on natural treatments for age-related diseases like osteoporosis and Alzheimer’s disease, visit

Journal Reference:

Alkhouli MF, Hung J, Squire M, Anderson M, Castro M, Babu JR, Al-Nakkash L, Broderick TL, Plochocki JH. EXERCISE AND RESVERATROL INCREASE FRACTURE RESISTANCE IN THE 3XTG-AD MOUSE MODEL OF ALZHEIMER’S DISEASE. BMC Complementary and Alternative Medicine. 4 February 2019; 19:39. DOI: 10.1186/s12906-019-2451-6

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