Colloidal silver made with ghanera extract has anticancer and antimicrobial potential – study
05/22/2019 // Evangelyn Rodriguez // Views

Ghanera (Nothapodytes nimmoniana) is a small flowering tree found in India. It bears oblong fruits which are purplish when ripe and contain only single seeds. Ghanera is known as a rich source of camptothecin (CPT), a topoisomerase inhibitor that can potentially treat ovarian and small lung cancers. Recently, researchers from Bharathidasan University in India discovered another application for ghanera: Its fruit extract can be used as a capping agent in the biosynthesis of nanoparticles that have strong anticancer and antimicrobial activities.

Why nanoparticles?

Nanoparticles have long been studied due to their potential in drug delivery. Researchers prefer to use them because they can be engineered to suit a specific purpose; for instance, they can target only diseased cells to allow for direct therapy. Nanoparticles, when used as vehicles, also reduce the damage done to healthy cells in the body because they can be more specific. They are also useful in medical diagnosis as they allow for the early detection of diseases.

Metal nanoparticles, on the other hand, are good stabilizing agents in the synthesis of nanoparticles because of their electrical, optical, chemical, and mechanical properties. In this study, published in the journal Food Science and Human Wellness, the researchers synthesized silver nanoparticles (AgNPs) and used a liquid extract from ripe ghanera fruit as capping agent. Capping agents are often used in the synthesis of colloids to stop overgrowth and control the structural characteristics of nanoparticles.


The researchers characterized the AgNPs they produced using UV analysis and x-ray diffraction. They used scanning electron microscopy to confirm that the AgNPs had a spherical shape and that the particles differed in size.

AgNPs made with ghanera fruit extracts can defend against bacteria and kill cancer cells

The researchers compared the ghanera fruit extract and the AgNPs in terms of phenolics, tannins, and flavonoid content. As they expected, the fruit extract had higher amounts of each compound than the AgNPs. It also exhibited better antioxidant activity, proving that the ghanera fruit is rich in phytochemicals that can fight oxidative stress.

In terms of antimicrobial activity, AgNPs proved to be more potent against Bacillus subtilisPseudomonas aeruginosaKlebsiella pneumoniaeStaphylococcus aureus, and Escherichia coliB. subtilis causes gastrointestinal tract infection in humans while P. aeruginosaK. pneumoniae, and S. aureus cause respiratory tract infections. E. coli is part of the normal human gut microflora, but some strains can cause urinary tract infections, abdominal cramps, anemia, and even kidney failure.

The researchers found the AgNPs with smaller particle sizes to be more effective against bacteria due to their large surface areas. Having large surface areas, they explained, meant that there was more space for interacting with bacteria. They also proposed that AgNPs kill bacteria by attaching to their cell surface and disrupting their permeability and respiration. AgNPs may also have the ability to penetrate inside bacterial cells.

When researchers tested the cytotoxicity of both ghanera extract and AgNPs on HeLa cells, they found that AgNPs can inhibit the proliferation of that cancer cell line. They observed that cell viability decreased as they increased the concentration of AgNPs, suggesting that AgNPs have strong anticancer potential. (Related: Rhubarb can destroy cancer cells.)

Based on their findings, the researchers concluded that AgNPs synthesized using ghanera fruit extract can be a promising candidate for biomedical applications due to their potent antimicrobial and anticancer activities.

Sources include:

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.