Can walnuts prevent inflammation and brain decline?
04/16/2019 // Michelle Simmons // Views

Eating walnuts is a great way to protect yourself from diseases. In particular, it may help fight inflammation and prevent brain decline, according to a new study published in the journal Nutrition Research.

Researchers at Tufts University hypothesized that whole walnut extract inhibits lipopolysaccharide (LPS)-induced microglial activation by regulating calmodulin expression through calcium ions. They tested their hypothesis by treating a rat microglial cell line with different concentrations of whole walnut extracts.

The researchers found that treatment with whole walnut extract resulted in a slow increase in intracellular calcium in a dose- and time-dependent manner. This increase became amplified when cells were depolarized with potassium chloride.

In addition, whole walnut extract treatment also increased calmodulin protein levels in cells, regardless of the concentration levels. This increase was inhibited when the researchers pretreated cells with thapsigargin, a tumor promoter in mammalian cells.

Moreover, treatment with whole walnut extract one hour before LPS induction effectively prevented the rise of inducible nitric oxide synthase expression, increase of ionized calcium ion-binding adaptor-1, and downregulation of calmodulin. Overall, these findings suggest that walnuts contain bioactive compounds that help regulate inflammatory responses in the brain.

From these findings, the researchers suggest that walnuts may be used to reduce chronic inflammation and prevent brain degeneration.

Walnut consumption may prevent Alzheimer's disease

An earlier study has revealed that walnuts provide protection against Alzheimer's disease, the most common neurodegenerative disease. Published in the Journal of Alzheimer's Disease, the animal study discovered that adhering to a walnut-enriched diet can lead to significant improvements in learning skills, memory, and motor development. Additionally, it can reduce anxiety.


For the study, the researchers looked at the effects of dietary walnut supplementation on mice. To do this, they fed mice with a diet consisting of six or nine percent walnuts. These are equivalent to an ounce and 1.5 ounces per day, respectively, of walnuts in humans. The results revealed that that feeding mice with a walnut-enriched diet improved the animals' cognitive function, motor development, and behavior.

The researchers suggested that the ability of walnuts to help reduce the risk, delay the onset, or hamper the progression of Alzheimer's disease may be attributed to the high antioxidant content of walnuts. Walnuts contain 3.7 millimoles per ounce (mmol/oz). Antioxidants fight oxidative stress and inflammation -- both of which are prominent characteristics of Alzheimer's disease. (Related: Walnuts rank as top nut, providing highest level of quality antioxidants.)

In addition, walnuts are the only type of nuts that contain high amounts of alpha-linolenic acid (ALA), which is an omega-3 fatty acid that has been shown to provide heart- and brain-health benefits. The researchers also suggested that this fatty acid may have contributed to the improvement of behavioral symptoms seen in the study.

"These findings are very promising and help lay the groundwork for future human studies on walnuts and Alzheimer's disease - a disease for which there is no known cure," said Abha Chauhan, leader of the study and head of the Developmental Neuroscience Laboratory at the New York State Institute for Basic Research in Developmental Disabilities (IBR).

Chauhan previously led a cell culture study that focused on the protective effects of walnut extract against the oxidative damage caused by amyloid beta protein. This protein is the primary component of amyloid plaques that form in the brains of people with Alzheimer's disease.

Read more news stories and studies on the health benefits of walnut consumption by going to

Sources include:

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.